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MTOR

mTOR

Struktur yang tersedia

PDB

Pencarian ortolog: PDBe RCSB

Daftar kode ID PDB
4JT6, 1AUE, 1FAP, 1NSG, 2FAP, 2GAQ, 2NPU, 2RSE, 3FAP, 4DRH, 4DRI, 4DRJ, 4FAP, 4JSN, 4JSP, 4JSV, 4JSX, 4JT5, 5FLC

Pengidentifikasi

Alias

MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS, mechanistic target of rapamycin, mechanistic target of rapamycin kinase

ID Eksternal

OMIM: 601231; MGI: 1928394; HomoloGene: 3637; GeneCards: MTOR; OMA:MTOR - orthologs

Lokasi gen (Manusia)

Kr.	Kromosom 1 (manusia)^[1]

Pita	1p36.22	Awal	11,106,535 pb^[1]
Pita	1p36.22	Akhir	11,262,551 pb^[1]

Lokasi gen (Tikus)

Kr.	Kromosom 4 (tikus)^[2]

Pita	4 E2\|4 78.76 cM	Awal	148,533,068 pb^[2]
Pita	4 E2\|4 78.76 cM	Akhir	148,642,140 pb^[2]

Pola ekspresi RNA

Bgee

Manusia

Tikus (ortologi)

Ekspresi tertinggi di

Gonad

right hemisphere of cerebellum

left testis

right testis

Otot gastrocnemius

right frontal lobe

muscle of thigh

Testis

ventricular zone

apex of heart

Ekspresi tertinggi di

spermatid

spermatocyte

right kidney

dentate gyrus of hippocampal formation granule cell

superior frontal gyrus

genital tubercle

primary visual cortex

muscle of thigh

ventricular zone

neural layer of retina

Referensi data ekspresi selengkapnya

BioGPS


Data ekspresi referensi lebih lanjut

Ontologi gen
Fungsi molekuler	protein domain specific binding TFIIIC-class transcription factor complex binding kinase activity ATP binding protein serine/threonine kinase activity transferase activity ribosome binding Ikatan protein plasma protein kinase binding nucleotide binding phosphoprotein binding protein kinase activity protein-containing complex binding pengikatan protein identik translation regulator activity
Komponen seluler	sitoplasma sitosol phosphatidylinositol 3-kinase complex membran mitokondria TORC1 complex organelle membrane protein-containing complex mitochondrial outer membrane Retikulum endoplasma TORC2 complex badan Golgi intracellular membrane-bounded organelle nucleoplasm soma PML body endoplasmic reticulum membrane Golgi membrane lysosomal membrane Dendrit Sistem endomembran Inti sel Lisosom glutamatergic synapse postsynaptic cytosol
Proses biologis	germ cell development positive regulation of protein phosphorylation response to amino acid positive regulation of lipid biosynthetic process positive regulation of actin filament polymerization positive regulation of skeletal muscle hypertrophy positive regulation of granulosa cell proliferation regulation of carbohydrate utilization post-embryonic development positive regulation of dendritic spine development positive regulation of translation positive regulation of eating behavior protein phosphorylation mRNA stabilization cell projection organization regulation of glycogen biosynthetic process positive regulation of cell growth involved in cardiac muscle cell development positive regulation of neuron maturation positive regulation of glial cell proliferation respons seluler terhadap hipoksia negative regulation of cell size response to cocaine positive regulation of protein kinase B signaling cardiac muscle contraction maternal process involved in female pregnancy ruffle organization regulation of GTPase activity cardiac muscle cell development positive regulation of transcription of nucleolar large rRNA by RNA polymerase I regulation of membrane permeability response to insulin regulation of myelination regulation of fatty acid beta-oxidation regulation of osteoclast differentiation positive regulation of cholangiocyte proliferation regulation of protein kinase B signaling spinal cord development positive regulation of peptidyl-tyrosine phosphorylation perilaku sosial protein autophosphorylation negative regulation of cholangiocyte apoptotic process regulation of brown fat cell differentiation regulation of protein kinase activity negative regulation of protein phosphorylation positive regulation of oligodendrocyte differentiation regulation of carbohydrate metabolic process regulation of actin cytoskeleton organization voluntary musculoskeletal movement Fosforilasi multicellular organism growth negative regulation of muscle atrophy wound healing positive regulation of neurogenesis response to morphine positive regulation of sensory perception of pain Katabolisme protein 'de novo' pyrimidine nucleobase biosynthetic process cellular response to nutrient levels energy reserve metabolic process peptidyl-threonine phosphorylation positive regulation of transcription by RNA polymerase III positive regulation of smooth muscle cell proliferation visual learning positive regulation of myotube differentiation positive regulation of cell death positive regulation of endothelial cell proliferation negative regulation of iodide transmembrane transport cardiac muscle tissue development positive regulation of nitric oxide biosynthetic process regulation of response to food heart morphogenesis positive regulation of neuron death cardiac cell development negative regulation of protein ubiquitination brain development positive regulation of gene expression long-term memory heart valve morphogenesis peptidyl-serine phosphorylation positive regulation of neuron projection development regulation of cellular response to heat positive regulation of lamellipodium assembly positive regulation of stress fiber assembly signal transduction regulation of protein phosphorylation negative regulation of macroautophagy anoikis TOR signaling Reparasi DNA regulation of cell size negative regulation of autophagy positive regulation of epithelial to mesenchymal transition regulation of macroautophagy cellular response to amino acid starvation positive regulation of keratinocyte migration cellular response to amino acid stimulus cellular response to leucine positive regulation of wound healing, spreading of epidermal cells cellular response to leucine starvation cellular response to starvation TORC1 signaling Pertumbuhan tanaman regulation of cell growth response to nutrient activation of protein kinase B activity T-helper 1 cell lineage commitment response to activity positive regulation of phosphoprotein phosphatase activity negative regulation of calcineurin-NFAT signaling cascade regulation of translation at synapse, modulating synaptic transmission positive regulation of cytoplasmic translational initiation response to nutrient levels
Sumber:Amigo / QuickGO

Ortologi

Spesies

Manusia

Tikus

Entrez


2475


56717

Ensembl


ENSG00000198793


ENSMUSG00000028991

UniProt


P42345


Q9JLN9

RefSeq (mRNA)


NM_004958 NM_001386500 NM_001386501


NM_020009

RefSeq (protein)


NP_004949


NP_064393

Location (UCSC)

Chr 1: 11.11 – 11.26 Mb

Chr 4: 148.53 – 148.64 Mb

PubMed search

^[3]

^[4]

Wikidata

Lihat/Sunting Manusia

Lihat/Sunting Tikus

MTOR adalah berkas genetik pada kromosom 1 lokasi 1p36.2 dengan ekspresi berupa enzim jenis kinase dengan aktivitas enzimatik yang terkait dengan keluarga enzim fosfatidil inositol kinase, termasuk serina/treonina kinase.^[5]

Rujukan

1 2 3 GRCh38: Ensembl release 89: ENSG00000198793 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028991 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ (Inggris) "MTOR mechanistic target of rapamycin (serine/threonine kinase) [ Homo sapiens ]". Entrez Gene. Diakses tanggal 2010-11-03.

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