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EIF2AK4

Struktur yang tersedia

PDB

Pencarian ortolog: PDBe RCSB

Daftar kode ID PDB
1UKX, 4OTN

Pengidentifikasi

Alias

EIF2AK4, GCN2, PVOD2, eukaryotic translation initiation factor 2 alpha kinase 4

ID Eksternal

OMIM: 609280; MGI: 1353427; HomoloGene: 40891; GeneCards: EIF2AK4; OMA:EIF2AK4 - orthologs

Lokasi gen (Manusia)

Kr.	Kromosom 15 (manusia)^[1]

Pita	15q15.1	Awal	39,934,115 pb^[1]
Pita	15q15.1	Akhir	40,035,591 pb^[1]

Pola ekspresi RNA

Bgee

Manusia

Tikus (ortologi)

Ekspresi tertinggi di

Adenohipofisis

bone marrow cell

stromal cell of endometrium

Membran sinovial

Tulang kering

Tendon Achilles

Brodmann area 9

nucleus accumbens

left uterine tube

caudate nucleus

Ekspresi tertinggi di

medullary collecting duct

secondary oocyte

primary oocyte

Zigot

Sacculus dan utriculus

otic placode

Paneth cell

external carotid artery

epithelium of lens

internal carotid artery

Referensi data ekspresi selengkapnya

BioGPS

n/a

Ontologi gen
Fungsi molekuler	transferase activity nucleotide binding protein kinase activity tRNA binding kinase activity protein serine/threonine kinase activity RNA binding ATP binding eukaryotic translation initiation factor 2alpha kinase activity
Komponen seluler	sitoplasma polysome cytosolic ribosome
Proses biologis	positive regulation of translational initiation in response to starvation adaptive immune response negative regulation of neuron differentiation positive regulation of long-term synaptic potentiation positive regulation of adaptive immune response negative regulation of translational initiation in response to stress negative regulation of translational initiation Fosforilasi immune system process cellular response to UV cellular response to amino acid starvation negative regulation of CREB transcription factor activity regulation of feeding behavior belajar perkembangan sistem saraf viral translation neuron projection extension protein phosphorylation cellular response to cold long-term memory defense response to virus cellular response to leucine starvation eiF2alpha phosphorylation in response to endoplasmic reticulum stress induction by virus of host autophagy protein autophosphorylation Siklus sel negative regulation by host of viral genome replication viral process regulation of translation regulation of translational initiation positive regulation of defense response to virus by host T cell activation involved in immune response DNA damage checkpoint signaling regulation of translational initiation by eIF2 alpha phosphorylation
Sumber:Amigo / QuickGO

Ortologi

Spesies

Manusia

Tikus

Entrez


440275


27103

Ensembl


ENSG00000128829


ENSMUSG00000005102

UniProt


Q9P2K8


Q9QZ05

RefSeq (mRNA)


NM_001013703


NM_001177806 NM_013719 NM_001355383

RefSeq (protein)


NP_001013725


NP_001171277 NP_038747 NP_001342312

Location (UCSC)

Chr 15: 39.93 – 40.04 Mb

n/a

PubMed search

^[2]

^[3]

Wikidata

Lihat/Sunting Manusia

Lihat/Sunting Tikus

Eukaryotic translation initiation factor 2-alpha kinase 4 adalah enzim yang disandikan oleh gen EIF2AK4 dalam tubuh manusia.^[4]^[5]

Dalam kedokteran

Mutasi pada gen ini dapat memicu hipertensi paru.^[6]

Referensi

1 2 3 GRCh38: Ensembl release 89: ENSG00000128829 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Berlanga JJ, Santoyo J, De Haro C (Nov 1999). "Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase". Eur J Biochem. 265 (2): 754–62. doi:10.1046/j.1432-1327.1999.00780.x. PMID 10504407.
↑ "Entrez Gene: EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4".
↑ Eyries M, Montani D, Girerd B et al. EIF2AK4 mutations cause pulmonary veno-occlusive disease, a recessive form of pulmonary hypertension, Nat Genet, 2014;46:65–69

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